Urine Bone Marker

Urine Bone Marker - Dpd (deoxypyridinoline crosslink)

Aeron's Dpd assay measures Deoxypyridinoline, a crosslink of Type 1 Collagen found almost exclusively in bone. Dpd is released into the circulation during the bone remodeling process, when osteoclasts degrade bone. Dpd is a s sensitive and specific marker of bone resorption. "

Dpd is excreted unmetabolized in urine and is unaffected by diet, making it suitable for assessing resorption. The Dpd assay should be performed using preservative free first or second morning voided urine collections. Dpd is stable in urine at room temperature for at least two weeks.

Dpd allows physicians to ....

Identify patients with increased bone resorption

Monitor patients on anti-resorptive therapies

The American Association of Clinical Endocrinology Guidelines for Postmenopausal Osteoporosis state:

"Biochemical markers of bone turnover may be useful for the following situations:
1. Assessing fracture risk in elderly patients
2. Assessing therapeutic responses to antiresorptive agents, such as estrogen and bisphosphonates
3. Identifying patients with high bone turnover"

The American Medical Association, American College of Clinical Endocrinology, American Society for Bone and Mineral Research and the International Society for Clinical Densitometry has endorsed Dpd testing.