Saliva Testing Bibliography

Peer-reviewed journal articles specific for each hormone tested by Aeron LifeCycles Clinical Laboratory appear under References within the hormone technical information and range sheets accessed from Saliva Analysis

1. Lu Y, Bentley GR, Gann PH, Hodges KR, Chatterton RT. Salivary estradiol and progesterone levels in conception and nonconception cycles in women: evaluation of a new assay for salivary estradiol. Fertility and Sterility 1999;71(5):863-868.

"Salivary steroids are thought to reflect the concentration of unbound serum steroids. In this respect the salivary concentrations may be a better measure of the exposure of target organs to the steroids than the serum concentrations are." The researchers go on to say, "The salivary methods have the advantage that the multiple samples can be collected at home by the patient or research subject, providing more information than can be obtained from a single serum sample and without the need for phlebotomy".

2. Malamud D. Saliva as a diagnostic fluid. BMJ 1992 Jul 25;305 (6847):207-8.

"Interest has been increasing in non-invasive diagnostic testing. Some of this attention stems from the AIDS epidemic, which has provided a new rationale for haemophobia, while other factors include new developments in home based diagnostic tests, a demand for samples collected in the home or workplace, and the close linkage of biotechnology to diagnostic tests. Tests based on saliva have already made substantial inroads into diagnosis. New collecting devices should make doctors more comfortable with using saliva as an alternative to blood".

3. Mandel ID. The diagnostic uses of saliva. J Oral Pathol Med 1990; 19:119-25.

"It is becoming increasingly apparent to investigators and clinicians in a variety of disciplines that saliva has many diagnostic uses. . .The highly sensitive test procedures that are now commonplace makes it practical to quantitate, despite very low concentrations, a large number of hormones and drugs in saliva. Indeed, all steroids of diagnostic significance in routine clinical endocrinology can now be readily measured in saliva. . .Saliva has found use as a diagnostic aid in an increasing number of clinical situations and in systemic diseases that can affect salivary gland function and composition".