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Estrone
Estrone is one of the three naturally occurring estrogens,
the others being estradiol and estriol. Estrone is produced primarily from
androstenedione originating from the gonads or the adrenal cortex. In
premenopausal women, more than 50% of the estrone is secreted by the ovaries. In
prepubertal children, men and non-supplemented postmenopausal women the major
portion of estrone is derived from peripheral tissue conversion of
androstenedione. Interconversion of estrone and estradiol also occurs in
peripheral tissue. Bioassay data indicate that the estrogenic action is much
less than estradiol. Estrone is a primary estrogenic component of several
pharmaceutical preparations, including those containing conjugated and
esterified estrogens. In premenopausal women estrone levels generally parallel
those of estradiol. After menopause estrone levels increase, possibly due to
increased conversion of androstenedione to estrone.
Interpretation of Results
Salivary levels of naturally produced hormones reflect the
free fraction (non-protein bound fraction) of the hormone in the blood. Levels
are about 1- 8% of the total serum concentration (although individual
variability is relatively broad). Salivary levels of those on oral replacement
show the same pattern. Trough levels are just prior to next scheduled dose and
were used to determine our ranges.
A normal range of estrone in saliva without
supplementation for both female and male is 2.6 - 5.4 pg/ml.
References
1) Baird DT, Fraser IS: Blood production and ovarian
secretion rates of estradiol - 17B and estrone in women throughout the menstrual
cycle. J Clin Endocrinol Metab 1974;38:1009
2) Grodin JM, Siiteri PK, MacDonald PC: Source of estrogen
production in postmenopausal women. J Clin Endocrinal Metab 1973;26:207
3) Longcope C: The endocrinology of the menopause. In:
Treatment of the Postmenopausal Woman. Lobo RA, ed., Raven Press, New York, NY
1993:47
4) Lobo RA: Treatment of the postmenopausal woman: Where
we are today. In: Treatment of the Postmenopausal Woman. Lobo RA, ed., Raven
Press, New York, NY 1993:47
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